Protection afforded by preconditioning to the diabetic heart against ischaemic injury
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چکیده
منابع مشابه
Protection afforded by preconditioning to the diabetic heart against ischaemic injury.
OBJECTIVE The aim of this study was to assess whether the cardioprotective effect of ischaemic preconditioning (IPC) on endothelial function in coronary arteries and myocardial function is affected in the streptozotocin-induced diabetic rat heart. METHODS Isolated hearts, perfused under constant flow conditions, were exposed to 30 min of partial ischaemia (flow rate 1 ml min-1) followed by 20...
متن کاملProtection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.
BACKGROUND Preconditioning (5 minutes of ischemia followed by 10 minutes of recovery) renders the heart very resistant to infarction from subsequent ischemia. This study tests whether adenosine receptors might mediate preconditioning protection. METHODS AND RESULTS We examined the effect on infarct size of pretreatment with either of two adenosine receptor antagonists in both control and prec...
متن کاملHyperoxic preconditioning fails to confer additional protection against ischemia-reperfusion injury in acute diabetic rat heart
Experimental studies show that detrimental effects of ischemia-reperfusion (I/R) injury can be attenuated by hyperoxic preconditioning in normal hearts, however, there are few studies about hyperoxia effects in diseased myocardium. The present study was designed to assess the cardioprotective effects of hyperoxia pretreatment (≥ 95 % O2) in acute diabetic rat hearts. Normal and one week acute d...
متن کاملIschaemic preconditioning of skeletal muscle. 1. Protection against the structural changes induced by ischaemia/reperfusion injury.
Ischaemic preconditioning is a process by which exposure of a tissue to a short period of non-damaging ischaemic stress leads to resistance to the deleterious effects of a subsequent prolonged ischaemic stress. It has been extensively described in the heart, but few studies have examined the possibility that it can occur in skeletal muscle. We have used a rat model of ischaemia of one limb to e...
متن کاملContribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart.
The aim of the present study was to assess the contribution of endogenous cannabinoids in the protective effect of ischemic preconditioning on the endothelial function in coronary arteries of the rat. Isolated rat hearts were exposed to a 30-min low flow ischemia (1 ml/min) followed by 20-min reperfusion, after which the response to the endothelium-dependent vasodilator, serotonine (5-HT), was ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1998
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(97)00234-4